Lysosomal chymotrypsin B potentiates apoptosis via cleavage of Bid

We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stored in lysosomes. Herein, we demonstrated a broad distribution of CtrB and explored the involvement of CtrB in apoptosis. Exposure of RH-35 cells to H₂O₂ or palmitate induced the redistribution of lysosomal CtrB into the cytoplasm as a result of lysosomal membrane permeabilization (LMP). Suppression of CtrB significantly blocked apoptosis, while overexpression of CtrB sensitized apoptosis markedly. CtrB could cleave Bid under neutral conditions. In RH-35 cells with Bid silenced, apoptosis induced by CtrB protein was attenuated, suggesting that CtrB mediates apoptosis of RH-35 cells mainly through processing Bid. Our data also suggest that LMP occurs earlier than mitochondrial outer membrane permeabilization; Bid activation initiated by caspase-8 might be reinforced by CtrB in consequence of LMP, which causes a positive feedback loop leading to the accumulation of tBid, and results in lysosome- and mitochondrion-dependent apoptosis.     

基于HLA的Agent-DEVS协同仿真建模

为实现DEVS在智能建模与分布仿真能力方面的扩充,研究了基于HLA的Agent-DEVS协同仿真建模方法.以并行DEVS为基础,提出了Agent-DEVS联邦模型的形式化描述;将Agent-DEVS模型端口转换为HLA数据对象,确定了Agent-DEVS联邦模型结构,并分析了通信机制,分别建立了Agent-DEVS的知...     

紫外光照射下钴钼杂多酸降解有机染料SRB

制备了不同配比的钴钼杂多酸（CoMox Heteropoly acids,CoMox）,在紫外光（λ≤387 nm）照射下,以有机染料酸性桃红（Sulforhodamine B,SRB）的光催化降解为探针反应,研究了CoMox杂多酸不同配比及用量和体系介质pH值对其降解行为的影响.结果表明,最佳配比的钴钼杂多酸为CoMo12,在pH=3.0,CoMo12用量为1.0 g/L时,对SRB降解效果最好.在紫外光照射下,CoMo12活化O2,3.5 h内SRB脱色率达到96%.通过紫外-可见吸收光谱（UV-vis absorption spectrum）,红外光谱（FTIR）和总有机碳（TOC）测定分析钴钼杂多酸对SRB的降解特性,同时采用苯甲酸荧光光度法跟踪测定降解过程中产生的活性氧化物种,表明CoMo12多酸对SRB的光催化降解过程主要涉及.OH氧化历程.     

子宫动脉栓塞术在难治性产后出血中的应用

目的:探讨子宫动脉栓塞术在产后出血中的应用。方法:对2008年3月—2011年1月铜川市妇幼保健院及泾阳县医院共10例产后出血应用双侧子宫动脉选择性造影及栓塞术后的观察效果。结果:10例产后出血患者经过双侧子宫动脉选择性造影及栓塞术后,止血时间3～8min,手术时间30～50min,DSA表现为宫腔内弥漫性、局灶性或单侧子宫动脉分支出血。10例均恢复月经周期,子宫得以保留,随访3-6月无严重并发症。结论:对难治性产后出血应用子宫动脉栓塞术微创临床效果好。     

浅谈变频器在输煤系统中的应用

在火力发电厂中,变频器已在机、炉等各系统的主要设备电气控制中普遍采用,随着变频技术的不断完善和变频器市场价格日益走低,输煤系统某些设备变频改造的需求日益强烈。文章将详细论述变频器在输煤系统中的应用价值,并解析其在应用过程中的常见故障、应对措施及谐波排除方案,以增强应用的可靠性和提高效率。     

2010年7月8日英山特大暴雨过程的成因分析

利用GFS(0.5°×0.5°)6 h再分析资料、LAPS资料以及FY-2c卫星云图资料、武汉区域雷达拼图产品和自动站实时资料,对2010年7月8日发生在英山的特大暴雨过程进行了分析.结果表明:控制湖北地区的副高南退时,副高外围东移的短波槽引导北方冷空气下滑是此次过程的触发机制;低层切变、低空急流、露点锋和地面辐合线引起了低层辐合、中层辐散、低层θse锋生及中上层θse锋区下移,提供了有利的动力条件;750～1 000 hPa的高湿区是水汽条件;温度槽温度脊的配合、对流有效位能的持续增加和湿位涡上正下负的配置为此次过程提供了不稳定能量.     

一种基于区分服务的IEEE 802.11 QoS信道访问控制机制

研究表明,无线移动自组织网络具有带宽有限,信道质量不稳定,节点移动造成网络拓扑结构变化等诸多特性,这些特性严重损害了网络性能,以致在传统无线移动网络中支持具有严格QoS要求的多媒体应用面临严峻的挑战.本文提出了一种基于区分服务的信道接入控制机制,以更好地支持实时通信流.该机制对传统的IEEE 802.11DCF机制进行...     

山西省“三农”问题浅议

围绕山西省农业发展的有利条件,分析了目前山西＂三农＂存在的主要问题,提出了尽快增加农民收入、提高粮食生产综合能力的对策。     

Performance Improvement of Distributed Systems by Autotuning of the Configuration Parameters

The performance of distributed computing systems is partially dependent on configuration parameters recorded in configuration files. Evolutionary strategies, with their ability to have a global view of the structural information, have been shown to effectively improve performance. However, most of these methods consume too much measurement time. This paper introduces an ordinal optimization based strategy combined with a back propagation neural network for autotuning of the configuration parameters. The strategy was first proposed in the automation community for complex manufacturing system optimization and is customized here for improving distributed system performance. The method is compared with the covariance matrix algorithm. Tests using a real distributed system with three-tier servers show that the strategy reduces the testing time by 40% on average at a reasonable performance cost.     

使用多方态的量子密钥共享方案(英文)

给出使用Sen等推广的多方对称态的量子密钥共享方案,我们采用不同的方法证明这个方案是安全的.然后,根据局域实在性的破缺,证明了对称的多方量子态的量子密钥共享的安全性,并作了进一步的推广.